Follicle.com - Topical minoxidil dose-response effect in alopecia areata

TITLE
Topical minoxidil dose-response effect in alopecia areata.

AUTHOR
Fiedler-Weiss VC; West DP; Buys CM; Rumsfield JA

SOURCE
Arch Dermatol 1986 Feb; 122 (2): 180-2

LANGUAGE OF ORIGIN
English

ABSTRACT
Topical 5% minoxidil solution was used to treat 47 patients with severe alopecia areata. Forty patients (85%) had terminal hair regrowth after 48 to 60 weeks of treatment. In the majority of patients, hair regrowth was not cosmetically acceptable. Data were compared with those from a previous study with topical 1% minoxidil solution. Both the percentage of responders and the quality of their hair regrowth were significantly greater with 5% than with 1% topical minoxidil solution. One patient developed an allergic contact dermatitis to minoxidil, but no systemic side effects were detected. The results strongly suggest a dose-response effect for topical minoxidil treatment of alopecia areata and the importance of exploring modifications in dosing and delivery systems to enhance therapeutic efficacy. (AUTHOR)

MJTR: Alopecia DT. Minoxidil AD.

MNTR: Administration, Topical. Adolescence. Adult. Child. Dose-Response Relationship, Drug. Female. Human. Male. Middle Age. Patch Tests. Solutions. Support, Non-U.S. Gov't. JOURNAL ARTICLE

RNUM: 0 (Solutions); 38304-91-5 (Minoxidil)

GEOT: UNITED STATES

IDEN: ISSN: 0003-987X. JOURNAL-CODE: 6WU. ENTRY-DATE: 860228. JOURNAL-SUBSET: A M X. IM-DATE: 8605.

ACCE: 86129520